BDBM50273442 2-(4-Chloro-6-(5-methoxy-2-methylbiphenyl-4-ylamino)pyrimidin-2-ylthio)octanoic acid::CHEMBL463776

SMILES CCCCCCC(Sc1nc(Cl)cc(Nc2cc(C)c(cc2OC)-c2ccccc2)n1)C(O)=O

InChI Key InChIKey=ORCISIWKCUVQKL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50273442   

TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50273442(2-(4-Chloro-6-(5-methoxy-2-methylbiphenyl-4-ylamin...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50273442(2-(4-Chloro-6-(5-methoxy-2-methylbiphenyl-4-ylamin...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli by cell-free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50273442(2-(4-Chloro-6-(5-methoxy-2-methylbiphenyl-4-ylamin...)
Affinity DataIC50: >10nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50273442(2-(4-Chloro-6-(5-methoxy-2-methylbiphenyl-4-ylamin...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50273442(2-(4-Chloro-6-(5-methoxy-2-methylbiphenyl-4-ylamin...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-LO in PMNL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed