BDBM50286724 (S)-3-Biphenyl-4-yl-2-((R)-2-mercapto-3-phenyl-propionylamino)-propionic acid::CHEMBL163454

SMILES OC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)[C@H](S)Cc1ccccc1

InChI Key InChIKey=BNECOBGISSOLPT-FCHUYYIVSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50286724   

TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286724((S)-3-Biphenyl-4-yl-2-((R)-2-mercapto-3-phenyl-pro...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286724((S)-3-Biphenyl-4-yl-2-((R)-2-mercapto-3-phenyl-pro...)
Affinity DataKi:  310nMAssay Description:Inhibition of human recombinant carboxy peptidase A1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286724((S)-3-Biphenyl-4-yl-2-((R)-2-mercapto-3-phenyl-pro...)
Affinity DataKi:  520nMAssay Description:Inhibition of human recombinant ACE by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286724((S)-3-Biphenyl-4-yl-2-((R)-2-mercapto-3-phenyl-pro...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286724((S)-3-Biphenyl-4-yl-2-((R)-2-mercapto-3-phenyl-pro...)
Affinity DataIC50:  688nMAssay Description:Inhibition of angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50286724((S)-3-Biphenyl-4-yl-2-((R)-2-mercapto-3-phenyl-pro...)
Affinity DataIC50:  100nMAssay Description:Inhibition of neutral endopeptidase (NEP) 24.11More data for this Ligand-Target Pair
In DepthDetails Article