BDBM50287555 CHEMBL4174695
SMILES Cc1noc(CNC(=O)c2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)n1
InChI Key InChIKey=DKFKIHZPQKGGTE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50287555
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 777nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells at -75 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 794nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair