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BDBM50296358 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid::1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid::AT-2266::CHEMBL826::CI-919::ENOXACIN::PD-107779::Penetrex::enofloxacin

SMILES: CCn1cc(C(O)=O)c(=O)c2cc(F)c(nc12)N1CCNCC1

InChI Key: InChIKey=IDYZIJYBMGIQMJ-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50296358   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
V-type proton ATPase subunit B, brain isoform


(Homo sapiens (Human))
BDBM50296358
PNG
(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Show SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(nc12)N1CCNCC1
Show InChI InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
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Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of Florida College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of maltose binding protein-fused human V-ATPase subunit B2 binding to F-actin


J Med Chem 52: 5144-51 (2010)


Article DOI: 10.1021/jm900277z
BindingDB Entry DOI: 10.7270/Q2K64J4W
More data for this
Ligand-Target Pair
Canalicular multispecific organic anion transporter 1


(Homo sapiens (Human))
BDBM50296358
PNG
(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Show SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(nc12)N1CCNCC1
Show InChI InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
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PubMed
n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair
Canalicular multispecific organic anion transporter 2


(Homo sapiens (Human))
BDBM50296358
PNG
(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Show SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(nc12)N1CCNCC1
Show InChI InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
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n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair
DNA gyrase subunit A/subunit B


(Escherichia coli)
BDBM50296358
PNG
(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Show SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(nc12)N1CCNCC1
Show InChI InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie-Paris 6

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli DNA gyrase GyrA/GyrB


Antimicrob Agents Chemother 52: 2909-14 (2008)


BindingDB Entry DOI: 10.7270/Q2862K8J
More data for this
Ligand-Target Pair
Multidrug resistance-associated protein 4


(Homo sapiens (Human))
BDBM50296358
PNG
(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Show SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(nc12)N1CCNCC1
Show InChI InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
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n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair
DNA gyrase subunit B


(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
BDBM50296358
PNG
(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Show SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(nc12)N1CCNCC1
Show InChI InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
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PubMed
n/an/a 1.56E+5n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie-Paris 6

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrB


Antimicrob Agents Chemother 52: 2909-14 (2008)


BindingDB Entry DOI: 10.7270/Q2862K8J
More data for this
Ligand-Target Pair
Bile salt export pump


(Homo sapiens (Human))
BDBM50296358
PNG
(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Show SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(nc12)N1CCNCC1
Show InChI InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
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Article
PubMed
n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair