BDBM50296531 CHEMBL550800::N-(5-(3,4-dichlorobenzyl)thiazol-2-yl)-3-(2-hydroxyethoxy)-4-methoxybenzamide

SMILES COc1ccc(cc1OCCO)C(=O)Nc1ncc(Cc2ccc(Cl)c(Cl)c2)s1

InChI Key InChIKey=LPRGOUWFYMYHEJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296531   

TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50296531(CHEMBL550800 | N-(5-(3,4-dichlorobenzyl)thiazol-2-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of SCD1 in mouse microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50296531(CHEMBL550800 | N-(5-(3,4-dichlorobenzyl)thiazol-2-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human SCD1 expressed in HEK293A cells assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50296531(CHEMBL550800 | N-(5-(3,4-dichlorobenzyl)thiazol-2-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of SCD1 in human microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed