BDBM50299777 CHEMBL573761::N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide::Oxo-3-phenylimidazolidine-1-carboxamide, 2

SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC

InChI Key InChIKey=MCTIWUDXKBCHRY-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50299777   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299777(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299777(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  10nMAssay Description:Inhibition assay using kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299777(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of GST-tagged c-Met expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299777(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  53nMAssay Description:Inhibition of HGF-mediated c-met autophosphorylation in serum-starved human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299777(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  80nMAssay Description:Inhibition of c-Met in human DU145 cells assessed as cell scatteringMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299777(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  90nMAssay Description:Inhibition of TPR-Met assessed as autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299777(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  30nMAssay Description:Inhibition assay using kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299777(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  80nMAssay Description:Inhibition of c-Met in human A549 cells by wound healing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed