BDBM50302107 CHEMBL567893::Grassystatin A

SMILES COC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](OC(=O)[C@@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)[C@@H](C)O

InChI Key InChIKey=JZYWSTGTBRHGTL-BIXXXADNSA-N

Data  75 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 75 hits for monomerid = 50302107   

TargetBeta-secretase 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of BACE1 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of cathepsin D in human MCF7 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin E after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  27nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin D after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  4.61E+4nMAssay Description:Inhibition of ADAM9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  0.886nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin X after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of cathepsin E in human MCF7 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of TACE after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of tryptase beta2 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ADAM9 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of calpain 1 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 1 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 2 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 3 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-4(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 4 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-5(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 5 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 6 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 7 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 8 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 9 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-10(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 10 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-4(Mus musculus)
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of mouse caspase 11 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-14(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 14 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin B after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin C after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin H after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin K after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin S after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin V after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin Z after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of chymase after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of DPP4 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of DPP8 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of DPP9 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1(Sus scrofa (Pig))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of porcine pancreatic elastase after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of factor 10a after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of factor 11a after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-4(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of kallikrein 4 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5 [D153N](Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of kallikrein 5 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-8(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of kallikrein 8 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of MMP1 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ADAM10 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of MMP2 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of MMP3 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of MMP7 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of MMP8 catalytic domain after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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