BDBM50303734 (S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL571320

SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=HZIOSWLCMNAEBB-RCRNZYILSA-N

Data  7 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50303734   

TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303734((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  4.02E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303734((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataEC50:  130nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303734((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  270nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303734((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataEC50:  230nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303734((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  5.95E+4nMAssay Description:Inhibition of human recombinant renin by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303734((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  1.11E+4nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303734((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  6.29E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303734((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  9.21E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303734((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair