BDBM50305629 CHEMBL589136::N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide

SMILES Clc1ccc(CNC(=O)N2CCC(CC2)Oc2ncccn2)c(Cl)c1

InChI Key InChIKey=UZEPPAOAIDTLTK-UHFFFAOYSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50305629   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  15nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid a...More data for this Ligand-Target Pair
TargetCytochrome P450 2J2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2J2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  63nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]-trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
TargetCytochrome P450 2J2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2J2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  2.55E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2J2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2J2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin...)
Affinity DataIC50:  11nMAssay Description:Inhibition of rat soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed