BDBM50305768 2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole::CHEMBL594902::MF-438

SMILES Cc1nnc(s1)-c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F

InChI Key InChIKey=NVUJDKDVOZVALT-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50305768   

TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  2nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  21nMAssay Description:Inhibition of SCD-1 activity in organic anion transporting polypeptides-deficient human HepG2 cells assessed as reduction in [I-14C] stearoyl CoA des...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  157nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat Hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [I-14C] st...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA (8-3)-desaturase(Rattus norvegicus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of rat delta-5 desaturase activity expressed in human HEpG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA 6-desaturase(Rattus norvegicus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of rat delta-6 desaturase activity expressed in human HEpG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA 6-desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of human delta6 desaturase activity expressed in human HEpG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA (8-3)-desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of human delta-5 desaturase activity expressed in human HEpG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed