BDBM50306504 4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-N-(2-methoxyphenyl)butanamide::CHEMBL591924

SMILES COc1ccccc1NC(=O)CC(Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)C(F)(F)F

InChI Key InChIKey=FVWWFRASLMZWEX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50306504   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306504(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of TPR-fused Met autophosphorylation expressed in HEK293T cells after 150 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306504(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of c-MET in human A549 cells by wound healing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306504(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  840nMAssay Description:Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306504(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306504(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of c-MET in human DU145 cells by scattering assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed