BDBM50310925 CHEMBL1081160::US9120807, 7::{6-dimethylamino-2-[(pyridine-3-ylmethyl)-amino]-thieno[3,2-d]pyrimidin-4-yl}-thiophen-2-yl-methanone

SMILES CN(C)c1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1

InChI Key InChIKey=VGLSCMPCDPYQTM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50310925   

TargetAdenosine receptor A1(Homo sapiens (Human))
Vernalis (R&D)

US Patent
LigandPNGBDBM50310925(CHEMBL1081160 | US9120807, 7 | {6-dimethylamino-2-...)
Affinity DataIC50:  19.4nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

US Patent
LigandPNGBDBM50310925(CHEMBL1081160 | US9120807, 7 | {6-dimethylamino-2-...)
Affinity DataIC50:  318nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

US Patent
LigandPNGBDBM50310925(CHEMBL1081160 | US9120807, 7 | {6-dimethylamino-2-...)
Affinity DataIC50:  1.42E+3nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3 [I248L](Homo sapiens (Human))
Vernalis (R&D)

US Patent
LigandPNGBDBM50310925(CHEMBL1081160 | US9120807, 7 | {6-dimethylamino-2-...)
Affinity DataIC50:  130nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310925(CHEMBL1081160 | US9120807, 7 | {6-dimethylamino-2-...)
Affinity DataIC50:  39nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310925(CHEMBL1081160 | US9120807, 7 | {6-dimethylamino-2-...)
Affinity DataIC50:  6.5nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In DepthDetails US Patent