BDBM50314070 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL1090089::pamapimod
SMILES Cn1c2nc(NC(CCO)CCO)ncc2cc(Oc2ccc(F)cc2F)c1=O
InChI Key InChIKey=JYYLVUFNAHSSFE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 50314070
Affinity DataKd: 1.30nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
Affinity DataKd: 1.30nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Binding affinity to JNK2More data for this Ligand-Target Pair
Affinity DataKd: 19nMAssay Description:Binding affinity to JNK3More data for this Ligand-Target Pair
Affinity DataKd: 170nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
Affinity DataKd: 190nMAssay Description:Binding affinity to JNK1More data for this Ligand-Target Pair
Affinity DataKd: 260nMAssay Description:Binding affinity to CSNK1epsilonMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of ADCK3More data for this Ligand-Target Pair
Affinity DataKd: 260nMAssay Description:Inhibition of CSNK1epsilonMore data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Roche Palo Alto
Curated by ChEMBL
Roche Palo Alto
Curated by ChEMBL
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of DDR1More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of STK36More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
Affinity DataIC50: >2.90E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: >2.90E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: >2.90E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: >2.90E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: >2.90E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: 5.42E+3nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair