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BDBM50316126 Bleph-10::Bleph-30::Blephamide::CHEMBL455::Cetamide::Cetapred::FML-S::Klaron::Metimyd::N-Acetyl-4-amino-benzenesulfonamide::Ocusulf-10::Ocusulf-30::Predamide::Predsulfair::SULF-10::SULF-15::SULFACETAMIDE::Sulfacel-15::Sulfacetamide, 1::Sulfair-15::Sulphacetamide::Sulphrin::Sulster::Sulten-10::Vasocidin

SMILES: CC(=O)NS(=O)(=O)c1ccc(N)cc1

InChI Key: InChIKey=SKIVFJLNDNKQPD-UHFFFAOYSA-N

Data: 1 KI  5 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50316126   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydrofolate reductase


(Homo sapiens (Human))
BDBM50316126
PNG
(Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
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MMDB

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n/an/a 1.80E+4n/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of human DHFR after 2 mins


Bioorg Med Chem 18: 2849-63 (2010)


Article DOI: 10.1016/j.bmc.2010.03.019
BindingDB Entry DOI: 10.7270/Q2M61M6S
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Bos taurus (Cattle))
BDBM50316126
PNG
(Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
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n/an/a 2.20E+4n/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of bovine DHFR after 2 mins


Bioorg Med Chem 18: 2849-63 (2010)


Article DOI: 10.1016/j.bmc.2010.03.019
BindingDB Entry DOI: 10.7270/Q2M61M6S
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50316126
PNG
(Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
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8.60E+4n/a 1.80E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Chem Biol Drug Des 76: 552-8 (2010)


Article DOI: 10.1111/j.1747-0285.2010.01036.x
BindingDB Entry DOI: 10.7270/Q2Q52N3T
More data for this
Ligand-Target Pair
Multidrug and toxin extrusion protein 1


(Homo sapiens (Human))
BDBM50316126
PNG
(Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay


J Med Chem 56: 781-95 (2013)


Article DOI: 10.1021/jm301302s
BindingDB Entry DOI: 10.7270/Q2F76DWZ
More data for this
Ligand-Target Pair
Bile salt export pump


(Homo sapiens (Human))
BDBM50316126
PNG
(Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
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Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...


Drug Metab Dispos 40: 2332-41 (2012)


Article DOI: 10.1124/dmd.112.047068
BindingDB Entry DOI: 10.7270/Q2ZP488M
More data for this
Ligand-Target Pair