BDBM50318653 3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxamide::3-amino-N-(3-fluorophenyl)-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carboxamide::CHEMBL1084955::NadD inhibitor 3_02::US8785499, 3_02

SMILES Nc1c(sc2nc(ccc12)-c1cccs1)C(=O)Nc1cccc(F)c1

InChI Key InChIKey=UCTSEHMMSSIODN-UHFFFAOYSA-N

Data  6 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50318653   

TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
University Of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of Bacillus anthracis nicotinate-nucleotide adenylyltransferase preincubated for 5 mins before addition of NaMN substrate by malachite gre...More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
University Of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  1.80E+4nM IC50:  3.60E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  2.10E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  2.50E+4nM IC50:  6.50E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
University Of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibition of Bacillus anthracis nicotinate-nucleotide adenylyltransferase preincubated for 5 mins before addition of ATP substrate by malachite gree...More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
University Of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  3.20E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataIC50:  6.50E+4nMpH: 7.5 T: 2°CAssay Description:A general phosphate detection assay method using Malachite Green reagent was adapted to measure the activity of NaMN adenylyltransferaseA14. Briefly,...More data for this Ligand-Target Pair
In DepthDetails US Patent