BDBM50318884 CHEMBL1084546::CHEMBL2430359::N-methyl-N-(3-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)methanesulfonamide::N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide::PF-562271
SMILES CN(c1ncccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O
InChI Key InChIKey=MZDKLVOWGIOKTN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50318884
Affinity DataKi: 1.20E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of FAK (unknown origin) using Poly(Glu,Tyr) and ATP as substrate measured after 40 mins by Kinase-Glo Plus luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PTK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Pyk2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Reversible inhibition of FAK kinase domain (amino acid 410-689) (unknown origin) assessed as inhibition of Phosphorylation of p(Glu/Tyr) by spectroph...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Competitive binding affinity to FAK kinase domain (410 to 689) (unknown origin) assessed as phosphorylation of p(Glu/Tyr) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Reversible/competitive inhibition of NH2-terminal His6-tagged FAK kinase domain (410 to 689 residues) (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PYK2 expressed in baculovirus infected sf21 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Reversible inhibition of NH2-terminal 6His-tagged FAK catalytic domain (410 to 689 residues) (unknown origin) expressed in Sf9 insect cells using p(G...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Reversible inhibition of PYK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 8.80E+4nMAssay Description:Binding affinity to captured wild-type human biotinylated Avi-tagged BCL6 BTB domain (5 to 129 amino acid residues) expressed in Escherichia coli BL2...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant FAK (410 to 689 residues) (unknown origin) using Poly (4:1 Glu, Tyr) peptide as substrate enzyme pretreated with substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of pyk2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of FAK (unknown origin) (410 to 689 residues) assessed as reduction in poly(Glu-Tyr) phosphorylation by absorbance methodMore data for this Ligand-Target Pair