BindingDB BDBM50339006 6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine::6-(2-aminopyrimidin-4-yl)-1H-indazol-3-amine::CHEMBL1688215

BDBM50339006 6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine::6-(2-aminopyrimidin-4-yl)-1H-indazol-3-amine::CHEMBL1688215

SMILES Nc1n[nH]c2cc(ccc12)-c1ccnc(N)n1

InChI Key InChIKey=QVWIVWPIJUYRRF-UHFFFAOYSA-N

Data 22 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50339006

TGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 1.59E+3nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Mitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 5.69E+3nMAssay Description:Inhibition of ASK1More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Aurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 398nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Aurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 3.16E+3nMAssay Description:Inhibition of aurora BMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Rho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 1.59E+3nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Inhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 100nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Aurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 3.48E+3nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: >1.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair

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Insulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: >1.00E+4nMAssay Description:Inhibition of INSMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase beta-1(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 6.34E+3nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair

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RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: >1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair

PDB Reactome pathway
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Insulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: >1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: >1.00E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: >1.00E+4nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Sgk1(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: >1.00E+4nMAssay Description:Inhibition of SGK1More data for this Ligand-Target Pair

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3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 370nMAssay Description:Inhibition of His-tagged-truncated human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 3 hrs by Scintillation proximi...More data for this Ligand-Target Pair

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3D Structure (crystal)

Cyclin-dependent kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 280nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair

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Aurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 390nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 840nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair

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Tyrosine-protein kinase JAK3(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 990nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair

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Tyrosine-protein kinase SYK(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 4.00E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair

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3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)

IC50: 398nMAssay Description:Inhibition of PDK1-mediated AKT phosphorylation at Thr308 residue in human PC3 cells by ELISAMore data for this Ligand-Target Pair

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3D Structure (crystal)

Filter my 22 hits

Targets 19▿
- 3-phosphoinositide-dependent protein kinase 1 2
- Aurora kinase B 2
- Aurora kinase A 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- TGF-beta receptor type-1 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Mitogen-activated protein kinase kinase kinase 5 1
- Insulin-like growth factor 1 receptor 1
- RAC-alpha serine/threonine-protein kinase 1
- Mitogen-activated protein kinase 8 1
- Cyclin-dependent kinase 2 1
- Tyrosine-protein kinase SYK 1
- Tyrosine-protein kinase JAK3 1
- Serine/threonine-protein kinase Chk1 1
- Ribosomal protein S6 kinase beta-1 1
- Rho-associated protein kinase 1 1
- Serine/threonine-protein kinase Sgk1 1
- Insulin receptor 1
- Vascular endothelial growth factor receptor 2 1
Publications 2▿
- ACS Med Chem Lett 1: 439-442 (2010) 17
- J Med Chem 54: 1871-95 (2011) 5
Institutions 2▿
- TBA 17
- Glaxosmithkline 5
Affinity: 1.0E+2 to 1.0E+4 nM▿
- IC50 22
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1