BDBM50345555 3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorobenzene::CHEMBL1784601

SMILES Cc1nc(cs1)C#Cc1cc(F)cc(c1)[N+]([O-])=O

InChI Key InChIKey=UZBIVMHNLNUAGH-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50345555   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345555(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorob...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345555(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorob...)
Affinity DataIC50:  0.610nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed