BDBM50352724 CHEMBL1822896::US8835436, Example 6

SMILES Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1

InChI Key InChIKey=JXNOGBVEQNMHDF-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50352724   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Green Cross

US Patent
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  18.6nMpH: 7.4Assay Description:For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Green Cross

US Patent
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  12.1nMpH: 7.4Assay Description:For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Green Cross

US Patent
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  10.2nMpH: 7.4Assay Description:For serotonin transporter binding assays, a reaction mixture with a final volume of 0.25 ml was prepared by mixing a test compound, human serotonin t...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of 5HT1A receptor by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  136nMAssay Description:Inhibition of 5HT6 receptor by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  11nMAssay Description:Inhibition of 5HT7 receptor by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Green Cross

US Patent
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  18.6nMAssay Description:Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  493nMAssay Description:Inhibition of dopamine D3 receptor by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50: >1.00E+4nMAssay Description:inhibition of dopamine D4 receptor by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  8.11E+3nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Green Cross

US Patent
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  12.1nMAssay Description:Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Green Cross

US Patent
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  10.2nMAssay Description:Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of dopamine D2 receptor by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed