BDBM50361645 CHEMBL1234429::US9873693, Compound 144

SMILES Fc1ccc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)c3ccccc3)c2=O)cc1F

InChI Key InChIKey=GCWCGSPBENFEPE-VWLOTQADSA-N

Data  1 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50361645   

Target3-phosphoinositide-dependent protein kinase 1 [51-360](Homo sapiens (Human))
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM50361645(CHEMBL1234429 | US9873693, Compound 144)
Affinity DataIC50: <500nMAssay Description:A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50361645(CHEMBL1234429 | US9873693, Compound 144)
Affinity DataEC50:  1nMAssay Description:Inhibition of PDK1-mediated AKT1 phosphorylation at T308 in human H460 cells after 2 hrs by ELISAMore data for this Ligand-Target Pair