BDBM50375318 Fungistat::Gyno-Terazol::Panlomyc::R-42470::TERCONAZOLE::Terazol::Terazol 3::Terazol 7::med.21724, Compound Terconazole

SMILES CC(C)N1CCN(CC1)c1ccc(OC[C@H]2CO[C@@](Cn3cncn3)(O2)c2ccc(Cl)cc2Cl)cc1

InChI Key InChIKey=BLSQLHNBWJLIBQ-OZXSUGGESA-N

Data  3 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50375318   

TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | TE...)
Affinity DataEC50:  1.41E+4nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Rattus norvegicus)
National Institutes Of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | TE...)
Affinity DataEC50:  9.10E+3nMAssay Description:Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | TE...)
Affinity DataEC50:  8.90E+3nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | TE...)
Affinity DataIC50:  410nMAssay Description:Inhibition of rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chromatographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
University Of Bonn

LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | TE...)
Affinity DataEC50:  1.22E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Bonn

LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | TE...)
Affinity DataEC50:  1.53E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | TE...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of rat brain microsome HO-2 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chromatographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Act

Curated by ChEMBL
LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | TE...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed