BDBM50382959 CEP-32496::CHEMBL2029988::US9730937, Example 261
SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC
InChI Key InChIKey=DKNUPRMJNUQNHR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 62 hits for monomerid = 50382959
Affinity DataKd: 99nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of Aurora B in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of ERK2 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of ERK1 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Inhibition of EPHA2 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 22nMAssay Description:Inhibition of EGFR in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 9nMAssay Description:Inhibition of CSF1R in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of Aurora A in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of ALK in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Inhibition of Abl1 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 39nMAssay Description:Inhibition of CRAF in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 36nMAssay Description:Inhibition of wild type BRAF in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of IGFR1 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of INSR in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of JAK1 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.70E+3nMAssay Description:Inhibition of JAK2 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of JAK3 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 2nMAssay Description:Inhibition of cKit in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 2nMAssay Description:Inhibition of LCK in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 7.10E+3nMAssay Description:Inhibition of MEK1 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 8.30E+3nMAssay Description:Inhibition of MEK2 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 513nMAssay Description:Inhibition of cMET in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 2nMAssay Description:Inhibition of PDGFRbeta in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of PIK3-CA in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of PIK3-CB in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of PLK1 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 2nMAssay Description:Inhibition of Ret in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 8nMAssay Description:Inhibition of VEGFR2 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Affinity DataKd: 375nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human RET kinase using IGF1Rtide as substrate incubated for 40 mins and measured by ADP-Glo assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 1.5nMAssay Description:Binding affinity to RET (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 36nMAssay Description:Binding affinity to BRAF (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Binding affinity to BRAF V600E (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 39nMAssay Description:Binding affinity to CRAF (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.80nMAssay Description:Binding affinity to ABL (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 7.90nMAssay Description:Binding affinity to VEGFR2 (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataKd: 14nMAssay Description:Binding affinity to FLT-1 (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 2.40nMAssay Description:Binding affinity to C-KIT (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of RET (unknown origin) by kinomescan assayMore data for this Ligand-Target Pair