BDBM50385915 CHEMBL2042135
SMILES C[C@@H](Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1cc(CN(C)C)cs1)\C=C/C(F)(F)F
InChI Key InChIKey=LLEOOSLUHRQCHZ-LMVHVUTASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50385915
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
3D Structure (crystal)TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of CDK2 by caliper methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of ABL at 1 uMMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of FYN incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of LYN incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CHK2 incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of MET incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of LCK incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 840nMAssay Description:Inhibition of SRC incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of GSK3beta incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of Nek2-mediated C-Nap1 phosphorylation in human U2OS cells after 3 hrs by immunofluorescence micrscopyMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 5.82E+3nMAssay Description:Inhibition of Plk1 using 5-FAMRRRAGALMDASFEEQ- CONH2 as substrate after 75 mins by caliper methodMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 8.47E+3nMAssay Description:Inhibition of MPS1 by caliper methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.94E+3nMAssay Description:Inhibition of Aurora A kinase by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of PKD2 incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair