BDBM50387058 CHEMBL2047045

SMILES CC(C)c1cccc(CNC[C@@H](O)[C@@H]2COC\C=C\C[C@@H](NC(=O)c3cc(C)cc(c3)C(=O)N2)c2ccccc2)c1

InChI Key InChIKey=BEGCWPHKTGGGNN-HOQOQLLYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50387058   

TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50387058(CHEMBL2047045)
Affinity DataIC50:  160nMAssay Description:Inhibition of BACE1 expressed in human HEK293 cells expressing Swedish mutant APP assessed as reduction on amyloid beta (1 to 40) production after 24...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50387058(CHEMBL2047045)
Affinity DataIC50:  78nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) cells using Swedish mutant sequence Eu-EVNLDAEFK-quencher at 10 uM after 60 mins by...More data for this Ligand-Target Pair