BDBM50398623 CHEMBL2177473

SMILES CC(C)Oc1cccc(CN2CC[C@]3(CN(C)S(=O)(=O)N3c3cccc(F)c3)C[C@@H]2C)c1

InChI Key InChIKey=CVPXZTQJPHYLAQ-YADARESESA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50398623   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398623(CHEMBL2177473)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of BACE1-mediated sAPPbeta production in human H4 cells expressing APP 695 after 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398623(CHEMBL2177473)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human recombinant BACE1 using K(biotin)RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair