BDBM50421415 CHEMBL414948

SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O

InChI Key InChIKey=SIIZPVYVXNXXQG-UQTMIEBXSA-N

Data  5 IC50  1 EC50

PDB links: 6 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50421415   

Target2-5A-dependent ribonuclease(Homo sapiens (Human))
National Institute Of Diabetes And Digestive Antd Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  13nMAssay Description:Displacement of the probe bound to Ribonuclease L by compound in radiobinding assay was evaluatedMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
National Institute Of Diabetes And Digestive Antd Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytesMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
National Institute Of Diabetes And Digestive Antd Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cellsMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  0.950nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
National Institute Of Diabetes And Digestive Antd Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataEC50:  0.210nMAssay Description:Binding affinity of compound to human recombinant Ribonuclease L was evaluatedMore data for this Ligand-Target Pair