BDBM50423645 Albamycin::Cathomycin::NOVOBIOCIN
SMILES [#6]-[#8]-[#6@@H]1-[#6@@H](-[#8]-[#6](-[#7])=O)-[#6@H](-[#8])-[#6@@H](-[#8]-c2ccc3c(-[#8])c(-[#7]-[#6](=O)-c4ccc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c4)c(=O)oc3c2-[#6])-[#8]C1([#6])[#6]
InChI Key InChIKey=YJQPYGGHQPGBLI-FWPHEPGVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50423645
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of BCRP expressed in MDCK cells by pheophorbide A assayMore data for this Ligand-Target Pair
Affinity DataIC50: 154nMAssay Description:Inhibition of Escherichia coli JM109 DNA gyrase subunit B assessed as ATP hydrolysis by ATPase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.14E+5nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.31E+5nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMT: 2°CAssay Description:Inhibition of Mycobacterium smegmatis DNA GyrB domain assessed as inhibition of inorganic phosphate release after 100 mins at room temperature by ATP...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of Mycobacterium smegmatis GyrB ATPase activity expressed in Escherichia coli BL21 (DE3) after 2 hrsMore data for this Ligand-Target Pair
Affinity DataKd: 1.20E+4nMAssay Description:Binding affinity to first site on human serum albumin by SPRMore data for this Ligand-Target Pair
Affinity DataKd: 28nMAssay Description:Binding affinity to Escherichia coli GyrBMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 6.61E+4nMAssay Description:Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assayMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of Streptococcus pneumoniae SP-3 gyrB by enzyme coupled phosphate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of Streptococcus pneumoniae SP-3 parE after 30 minsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 8.51E+4nMAssay Description:Inhibition of BCRP expressed in MDCK cells by pheophorbide A assayMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of reconstituted Escherichia coli DNA gyrase subunit AB assessed as reduction of DNA supercoiling activity using pBR322 DNA substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of Escherichia coli JM109 DNA gyrase subunit B assessed as DNA triple helix formation by supercoiling assayMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of purified Mycobacterium smegmatis GyrB at 50 to 100 uM after 100 mins by ATPase assayMore data for this Ligand-Target Pair