BDBM50426498 1,6-Dimethylcabergoline::CHEMBL2323579

SMILES CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](Cc3cn(C)c4cccc2c34)N(C)C1

InChI Key InChIKey=OQPYDZQJBICVMH-SYYKKAFVSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50426498   

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426498(1,6-Dimethylcabergoline | CHEMBL2323579)
Affinity DataKi:  1nMAssay Description:Displacement of [125I](+/-)DOI from human 5-HT2B receptor trasfected in CHO cell membrane after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426498(1,6-Dimethylcabergoline | CHEMBL2323579)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins befo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426498(1,6-Dimethylcabergoline | CHEMBL2323579)
Affinity DataIC50:  1.15E+4nMAssay Description:Antagonist activity at human 5-HT2A receptor assessed as decrease in agonist-induced intracellular calcium mobilization preincubated for 10 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426498(1,6-Dimethylcabergoline | CHEMBL2323579)
Affinity DataEC50:  1.40nMAssay Description:Partial agonist activity at human D2 receptor transfected in HTLA cells measured after overnight incubation by luminescence counter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed