BDBM50427065 CHEMBL2322875

SMILES COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1nc(c(Cl)c1C)C(F)(F)F

InChI Key InChIKey=PTHJVFQTMJMDKU-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50427065   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  1.60E+4nMAssay Description:Binding affinity to human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: >1.00E+4nMAssay Description:Competitive inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: >1.00E+4nMAssay Description:Competitive inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: >1.00E+4nMAssay Description:Competitive inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: >1.00E+4nMAssay Description:Competitive inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Mus musculus)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  900nMAssay Description:Antagonist activity at CCR1 in mouse WEHI274.1 cells assessed as inhibition of CCL3/MIP-1alpha-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Mus musculus)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  3.00E+3nMAssay Description:Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in mouse WEHI274.1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL23/CKbeta8.1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  5.5nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed