BDBM50431093 CHEMBL2338810

SMILES CS(=O)(=O)NCCC1CCN(CC1)c1ncnc2cc(sc12)C(N)=O

InChI Key InChIKey=BKOWIHMCGFRARN-UHFFFAOYSA-N

Data  3 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50431093   

TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris A Gsk

Curated by ChEMBL
LigandPNGBDBM50431093(CHEMBL2338810)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk

Curated by ChEMBL
LigandPNGBDBM50431093(CHEMBL2338810)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris A Gsk

Curated by ChEMBL
LigandPNGBDBM50431093(CHEMBL2338810)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s...More data for this Ligand-Target Pair