BDBM50442103 CHEMBL2441082

SMILES COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)N1CCC(F)(F)CC1

InChI Key InChIKey=RNAMYOYQYRYFQY-UHFFFAOYSA-N

Data  1 KI  10 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50442103   

TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataKi:  3.70nMAssay Description:Non-competitive inhibition of lysine methyltransferase G9a (unknown origin) using SAM as substrate by Michaelis-Menten kinetic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50:  40nMAssay Description:Inhibition of lysine methyltransferase G9a in human PANC1 cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell Western...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50:  130nMAssay Description:Inhibition of lysine methyltransferase G9a in human PC3 cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell Western a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50:  130nMAssay Description:Inhibition of lysine methyltransferase G9a in human U2OS cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell Western ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50:  110nMAssay Description:Inhibition of lysine methyltransferase G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell We...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: <2.5nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50:  220nMAssay Description:Inhibition of human G9a (913 to 1193 residues) using H3 peptide as substrate measured upto 45 mins in presence of SAM cofactorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50:  180nMAssay Description:Inhibition of human GLP (982 to 1266 residues) using H3 peptide as substrate measured upto 45 mins in presence of SAM cofactorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataKd:  62nMAssay Description:Binding affinity to human GLP (982 to 1266 residues) assessed as dissociation constant by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataKd:  230nMAssay Description:Binding affinity to human G9a (913 to 1193 residues) assessed as dissociation constant by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: <2.5nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed