BDBM50444941 CHEMBL3099755

SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cc(C(O)=O)c2cc(ccc2n1)-c1cccc(Cl)c1

InChI Key InChIKey=LTZGVONWBPMCBP-DEOSSOPVSA-N

Data  1 KI  1 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50444941   

TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50444941(CHEMBL3099755)
Affinity DataKi:  140nMAssay Description:Displacement of B-Alexa-Fluor647 from CDK2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50444941(CHEMBL3099755)
Affinity DataKd:  300nMAssay Description:Binding affinity to human CDK2 by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50444941(CHEMBL3099755)
Affinity DataKd:  300nMAssay Description:Binding affinity to CDK2 (unknown origin) at 20 to 80 degC by circular dichroism analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50444941(CHEMBL3099755)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:Inhibition of CDK2 (unknown origin)-cyclin A interaction preincubated for 30 mins at room temperature followed by incubation at 40 degC for 30 mins b...More data for this Ligand-Target Pair