BDBM50452209 CHEMBL4207777::US10647727, Example 9

SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(Cl)nc12

InChI Key InChIKey=YIIMIHLIRATCLN-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50452209   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50452209(CHEMBL4207777 | US10647727, Example 9)
Affinity DataKi:  3.40nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50452209(CHEMBL4207777 | US10647727, Example 9)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to PDE2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50452209(CHEMBL4207777 | US10647727, Example 9)
Affinity DataKi:  4.30nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent