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BDBM50453019 CHEMBL4206812

SMILES: Clc1cccc(NC(=O)c2coc3ccccc3c2=O)c1

InChI Key: InChIKey=CVLFPXGWUQAEEW-UHFFFAOYSA-N

Data: 3 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50453019   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50453019
PNG
(CHEMBL4206812)
Show SMILES Clc1cccc(NC(=O)c2coc3ccccc3c2=O)c1
Show InChI InChI=1S/C16H10ClNO3/c17-10-4-3-5-11(8-10)18-16(20)13-9-21-14-7-2-1-6-12(14)15(13)19/h1-9H,(H,18,20)
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Article
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0.790n/an/an/an/an/an/an/an/a



University of Porto

Curated by ChEMBL


Assay Description
Competitive inhibition of human microsomal MAO-B expressed in recombinant baculovirus infected insect BTI-TN-5B1-4 cells assessed as reduction in H2O...


J Med Chem 59: 5879-93 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00527
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50453019
PNG
(CHEMBL4206812)
Show SMILES Clc1cccc(NC(=O)c2coc3ccccc3c2=O)c1
Show InChI InChI=1S/C16H10ClNO3/c17-10-4-3-5-11(8-10)18-16(20)13-9-21-14-7-2-1-6-12(14)15(13)19/h1-9H,(H,18,20)
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7.5n/an/an/an/an/an/an/an/a



University of Porto

Curated by ChEMBL


Assay Description
Non-competitive inhibition of recombinant human MAO-B expressed in Pichia pastoris using benzylamine as substrate by fluorimetric horseradish peroxid...


J Med Chem 61: 4203-4212 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00357
BindingDB Entry DOI: 10.7270/Q2KH0QWD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50453019
PNG
(CHEMBL4206812)
Show SMILES Clc1cccc(NC(=O)c2coc3ccccc3c2=O)c1
Show InChI InChI=1S/C16H10ClNO3/c17-10-4-3-5-11(8-10)18-16(20)13-9-21-14-7-2-1-6-12(14)15(13)19/h1-9H,(H,18,20)
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17n/an/an/an/an/an/an/an/a



University of Porto

Curated by ChEMBL


Assay Description
Tight-binding competitive inhibition of recombinant human MAO-B expressed in Pichia pastoris using benzylamine as substrate by fluorimetric horseradi...


J Med Chem 61: 4203-4212 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00357
BindingDB Entry DOI: 10.7270/Q2KH0QWD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50453019
PNG
(CHEMBL4206812)
Show SMILES Clc1cccc(NC(=O)c2coc3ccccc3c2=O)c1
Show InChI InChI=1S/C16H10ClNO3/c17-10-4-3-5-11(8-10)18-16(20)13-9-21-14-7-2-1-6-12(14)15(13)19/h1-9H,(H,18,20)
PDB

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Article
PubMed
n/an/a 0.407n/an/an/an/an/an/a



University of Porto

Curated by ChEMBL


Assay Description
Inhibition of human microsomal MAO-B expressed in recombinant baculovirus infected insect BTI-TN-5B1-4 cells assessed as reduction in H2O2 production...


J Med Chem 59: 5879-93 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00527
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50453019
PNG
(CHEMBL4206812)
Show SMILES Clc1cccc(NC(=O)c2coc3ccccc3c2=O)c1
Show InChI InChI=1S/C16H10ClNO3/c17-10-4-3-5-11(8-10)18-16(20)13-9-21-14-7-2-1-6-12(14)15(13)19/h1-9H,(H,18,20)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of Porto

Curated by ChEMBL


Assay Description
Inhibition of human microsomal MAO-B expressed in recombinant baculovirus infected insect BTI-TN-5B1-4 cells assessed as reduction in H2O2 production...


J Med Chem 59: 5879-93 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00527
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)