BDBM50457307 CHEMBL4206684

SMILES [2H]C([2H])(O)c1ccc(C)c(Nc2nccc(n2)-c2cc3c(NC[C@]3(C)CO)c(c2)C#N)c1

InChI Key InChIKey=DJHBXXYGFAJRGL-CVWTWWASSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457307   

TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457307(CHEMBL4206684)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant human GST-tagged MAP3K14 autophosphorylation after 1 hr by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457307(CHEMBL4206684)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MAP3K14 in human L363 assessed as decrease in IKKalpha phosphorylation level after 2 hrs by sandwich immuno assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed