BDBM50457317 CHEMBL4214322::US10662187, Compound 9::US10793566, Compound 9

SMILES Clc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1

InChI Key InChIKey=ONDXAUUTDOFMBH-HXUWFJFHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50457317   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457317(CHEMBL4214322 | US10662187, Compound 9 | US1079356...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457317(CHEMBL4214322 | US10662187, Compound 9 | US1079356...)
Affinity DataIC50:  55nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457317(CHEMBL4214322 | US10662187, Compound 9 | US1079356...)
Affinity DataIC50:  55nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent