BDBM50457318 CHEMBL4218219::US10662187, Compound 45::US10793566, Compound 45

SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3CCN(Cc23)C(C)=O)c1F

InChI Key InChIKey=GMBJUSAQENNGCY-HXUWFJFHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50457318   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457318(CHEMBL4218219 | US10662187, Compound 45 | US107935...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457318(CHEMBL4218219 | US10662187, Compound 45 | US107935...)
Affinity DataIC50:  5.50E+3nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457318(CHEMBL4218219 | US10662187, Compound 45 | US107935...)
Affinity DataIC50:  5.50E+3nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent