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BDBM50463507 CHEMBL4247751

SMILES: Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12

InChI Key: InChIKey=CNEUJSQUCXSRDD-UHFFFAOYSA-N

Data: 1 IC50  8 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50463507   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activin receptor type-1


(Homo sapiens (Human))
BDBM50463507
PNG
(CHEMBL4247751)
Show SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12
Show InChI InChI=1S/C19H15N3O/c1-11-13(7-8-17-18(11)19(23)22-12(2)21-17)14-9-10-20-16-6-4-3-5-15(14)16/h3-10H,1-2H3,(H,21,22,23)
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n/an/an/a 640n/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to human ALK2 by KdELECT assay


J Med Chem 61: 7261-7272 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00782
BindingDB Entry DOI: 10.7270/Q2K64MRS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50463507
PNG
(CHEMBL4247751)
Show SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12
Show InChI InChI=1S/C19H15N3O/c1-11-13(7-8-17-18(11)19(23)22-12(2)21-17)14-9-10-20-16-6-4-3-5-15(14)16/h3-10H,1-2H3,(H,21,22,23)
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n/an/an/a 330n/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to partial length human RAF1 (I330 to T640 residues) expressed in bacterial expression system by KdELECT assay


J Med Chem 61: 7261-7272 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00782
BindingDB Entry DOI: 10.7270/Q2K64MRS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))
BDBM50463507
PNG
(CHEMBL4247751)
Show SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12
Show InChI InChI=1S/C19H15N3O/c1-11-13(7-8-17-18(11)19(23)22-12(2)21-17)14-9-10-20-16-6-4-3-5-15(14)16/h3-10H,1-2H3,(H,21,22,23)
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n/an/an/a 41n/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to human ALK1 by KdELECT assay


J Med Chem 61: 7261-7272 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00782
BindingDB Entry DOI: 10.7270/Q2K64MRS
More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50463507
PNG
(CHEMBL4247751)
Show SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12
Show InChI InChI=1S/C19H15N3O/c1-11-13(7-8-17-18(11)19(23)22-12(2)21-17)14-9-10-20-16-6-4-3-5-15(14)16/h3-10H,1-2H3,(H,21,22,23)
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n/an/an/a 65n/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRAF (S429 to E741 residues) expressed in mammalian expression system by KdELECT assay


J Med Chem 61: 7261-7272 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00782
BindingDB Entry DOI: 10.7270/Q2K64MRS
More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK-3)


(Homo sapiens (Human))
BDBM50463507
PNG
(CHEMBL4247751)
Show SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12
Show InChI InChI=1S/C19H15N3O/c1-11-13(7-8-17-18(11)19(23)22-12(2)21-17)14-9-10-20-16-6-4-3-5-15(14)16/h3-10H,1-2H3,(H,21,22,23)
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n/an/an/a 2.70E+3n/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to human ALK3 by KdELECT assay


J Med Chem 61: 7261-7272 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00782
BindingDB Entry DOI: 10.7270/Q2K64MRS
More data for this
Ligand-Target Pair
Activin receptor type-1B


(Homo sapiens (Human))
BDBM50463507
PNG
(CHEMBL4247751)
Show SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12
Show InChI InChI=1S/C19H15N3O/c1-11-13(7-8-17-18(11)19(23)22-12(2)21-17)14-9-10-20-16-6-4-3-5-15(14)16/h3-10H,1-2H3,(H,21,22,23)
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n/an/an/a 690n/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to human ALK4 by KdELECT assay


J Med Chem 61: 7261-7272 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00782
BindingDB Entry DOI: 10.7270/Q2K64MRS
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50463507
PNG
(CHEMBL4247751)
Show SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12
Show InChI InChI=1S/C19H15N3O/c1-11-13(7-8-17-18(11)19(23)22-12(2)21-17)14-9-10-20-16-6-4-3-5-15(14)16/h3-10H,1-2H3,(H,21,22,23)
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n/an/an/a 1.00E+3n/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to human ALK5 by KdELECT assay


J Med Chem 61: 7261-7272 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00782
BindingDB Entry DOI: 10.7270/Q2K64MRS
More data for this
Ligand-Target Pair
Activin receptor type-1


(Homo sapiens (Human))
BDBM50463507
PNG
(CHEMBL4247751)
Show SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12
Show InChI InChI=1S/C19H15N3O/c1-11-13(7-8-17-18(11)19(23)22-12(2)21-17)14-9-10-20-16-6-4-3-5-15(14)16/h3-10H,1-2H3,(H,21,22,23)
PDB

KEGG

UniProtKB/SwissProt
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PC cid
PC sid
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PDB
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n/an/a 42n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged human ALK2 catalytic domain (145 to 509 residues) expressed in Baculovirus expression system by FRET-based Lanth...


J Med Chem 61: 7261-7272 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00782
BindingDB Entry DOI: 10.7270/Q2K64MRS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495


(Homo sapiens (Human))
BDBM50463507
PNG
(CHEMBL4247751)
Show SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12
Show InChI InChI=1S/C19H15N3O/c1-11-13(7-8-17-18(11)19(23)22-12(2)21-17)14-9-10-20-16-6-4-3-5-15(14)16/h3-10H,1-2H3,(H,21,22,23)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/an/a 39n/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to human ALK6 by KdELECT assay


J Med Chem 61: 7261-7272 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00782
BindingDB Entry DOI: 10.7270/Q2K64MRS
More data for this
Ligand-Target Pair