BDBM50510795 CHEMBL4561849

SMILES [H][C@@]12CCN=[S@]1(=O)C(C)(C)C(N)=N[C@]2(C)c1cc(NC(=O)c2ncc(cc2C)C#N)ccc1F

InChI Key InChIKey=FDHZALOQNQTHFY-INCWNZBPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50510795   

TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510795(CHEMBL4561849)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP assessed as reduction in amyloidbeta 40 level incubated for 18 to 20 hrs by AlphaLISA AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed