BDBM50515431 CHEMBL4441357

SMILES Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccc(NS(=O)(=O)c3ccc(cc3)C#N)cc2)c1F

InChI Key InChIKey=JXUNVJWFIFYSLS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50515431   

Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515431(CHEMBL4441357)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515431(CHEMBL4441357)
Affinity DataIC50:  198nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstradiol 17-beta-dehydrogenase 2(Mus musculus)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515431(CHEMBL4441357)
Affinity DataIC50:  30nMAssay Description:Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed