BDBM50516235 CHEMBL4563408

SMILES FC(F)Oc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3n(c(nc23)-c2ccccc2Cl)-c2ccc(Cl)cc2)cn1

InChI Key InChIKey=LTNOPYMLPTUXSM-UHFFFAOYSA-N

Data  3 KI  40 IC50  41 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 84 hits for monomerid = 50516235   

TargetCannabinoid receptor 1(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]astemizole from human ERG measured after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha 1A adrenoceptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]WIN55212-2 from recombinant human CB2 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [125I]endothelin-1 from recombinant human ETA receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]DADLE from recombinant human DOR after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I](+/-)DOI from recombinant human 5HT2A receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]dexamethasone from recombinant human GR after 360 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]nitrendipine from rat brain Cav1.2 dihydropyridine site after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]CGS21680 from recombinant human adenosine A2A receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]CGS21680 from recombinant human adenosine A2A receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens)
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]RX 821002 from recombinant human alpha 2A adrenoceptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens)
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]RX 821002 from recombinant human alpha 2A adrenoceptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H](-)CGP12177 from recombinant human beta2 adrenergic receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H](-)CGP12177 from recombinant human beta2 adrenergic receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [125I]CCK-8s from recombinant human CCK1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]SCH23390 from recombinant human D1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]7-OH-DPAT from recombinant human D2s receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]7-OH-DPAT from recombinant human D2s receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]endothelin-1 from recombinant human ETA receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]APT from recombinant human H2 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from recombinant human M1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]AF-DX 384 from recombinant human M2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]4-DAMP from recombinant human M3 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]4-DAMP from recombinant human M3 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]U69593 from recombinant human KOR after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]U69593 from recombinant human KOR after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]GR125743 from recombinant human 5HT1B after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]GR125743 from recombinant human 5HT1B after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I](+/-)DOI from recombinant human 5HT2B receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]AVP from recombinant human V1A receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]AVP from recombinant human V1A receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]BTCP from recombinant human dopamine transporter after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]cytisine from recombinant human alpha4beta2 nAChR after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]BRL43694 from recombinant human 5HT3 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from recombinant human ERG after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]methyltrienolone from recombinant human AR after 1440 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]methyltrienolone from recombinant human AR after 1440 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at recombinant human LCK using Ulight-Poly GAT[EAY(1:1:1)]n as substrate measured after 10 mins by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human recombinant COX1 using arachidonic acid as substrate measured after 3 mins by ADHP reagent based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human recombinant COX1 using arachidonic acid as substrate measured after 3 mins by ADHP reagent based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human recombinant COX2 using arachidonic acid as substrate measured after 5 mins by ADHP reagent based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human recombinant ACHE using acetylthiocholine as substrate measured after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro41-1049 from rat brain MAOA after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Rti International

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro41-1049 from rat brain MAOA after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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