BDBM50517609 CHEMBL4440581

SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O

InChI Key InChIKey=SWTVTUVZIZCTLT-DNJSMDQWSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50517609   

TargetProteasome subunit beta type-1(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 20S constitutive proteasome beta 1 caspase-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50:  11nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 20S constitutive proteasome beta 5 chymotrypsin-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 20S immunoproteasome beta 5 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 20S immunoproteasome beta 1 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50:  6nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 20S constitutive proteasome beta 1 caspase-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 20S constitutive proteasome beta 5 chymotrypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 20S immunoproteasome beta 1 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50:  525nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of 20S immunoproteasome beta 5 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50:  230nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed