BDBM50518505 CHEMBL4518492

SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCCO3)n([C@H]3CCCNC3)c2n1

InChI Key InChIKey=ITQFRPBHRRDOKY-PXYINDEMSA-N

Data  1 KI  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50518505   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataKi:  1.30nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataIC50:  21nMAssay Description:Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataIC50:  21nMAssay Description:Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1/pim-2/pim-3(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataEC50:  137nMAssay Description:Inhibition of PIM in human KG1 cells assessed as reduction in pS6 levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1/pim-2/pim-3(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataEC50:  137nMAssay Description:Inhibition of PIM in human KG1 cells assessed as reduction in pS6 levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed