BDBM50518508 CHEMBL4533366

SMILES CC(C)(CC#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O)C(N)=O

InChI Key InChIKey=VUSIBGXJGOLGIN-NSHDSACASA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50518508   

TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518508(CHEMBL4533366)
Affinity DataIC50:  21nMAssay Description:Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1/pim-2/pim-3(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518508(CHEMBL4533366)
Affinity DataEC50:  133nMAssay Description:Inhibition of PIM in human KG1 cells assessed as reduction in pS6 levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518508(CHEMBL4533366)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518508(CHEMBL4533366)
Affinity DataIC50: >10nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed