BDBM50518791 CHEMBL4520147::US10829446, Compound 4

SMILES Cc1cccc(C(=O)NNS(=O)(=O)c2ccc3ccccc3c2)c1F

InChI Key InChIKey=DILVLVXPRQTRMP-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50518791   

TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
Cancer Therapeutics Crc

Curated by ChEMBL
LigandPNGBDBM50518791(CHEMBL4520147 | US10829446, Compound 4)
Affinity DataIC50:  120nMAssay Description:Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
Cancer Therapeutics Crc

Curated by ChEMBL
LigandPNGBDBM50518791(CHEMBL4520147 | US10829446, Compound 4)
Affinity DataIC50:  195nMAssay Description:Active Moz protein was expressed as N-terminal fusion protein with a His6 tag in BL21 E. coli cells. Protein purification was performed via nickel-im...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
Cancer Therapeutics Crc

Curated by ChEMBL
LigandPNGBDBM50518791(CHEMBL4520147 | US10829446, Compound 4)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 15 uM acetyl c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed