BDBM50519579 CHEMBL4576647

SMILES COc1cc(cnc1C(=O)[C@H]1C[C@@H]1C(O)=O)N(CC1CC1)c1ccc(F)c(Cl)c1

InChI Key InChIKey=QPKTZUADCFLINH-GJZGRUSLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50519579   

TargetLeukotriene C4 synthase(Homo sapiens (Human))
Orexo

Curated by ChEMBL
LigandPNGBDBM50519579(CHEMBL4576647)
Affinity DataIC50:  42nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Orexo

Curated by ChEMBL
LigandPNGBDBM50519579(CHEMBL4576647)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed