BDBM50520168 CHEMBL4549459::US10894784, Example 16.01.02

SMILES Cc1noc(n1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1

InChI Key InChIKey=UOPCRSIUYMGQCP-UHFFFAOYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50520168   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50520168(CHEMBL4549459 | US10894784, Example 16.01.02)
Affinity DataIC50:  129nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-6(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50520168(CHEMBL4549459 | US10894784, Example 16.01.02)
Affinity DataIC50:  8.91E+3nMAssay Description:Inhibition of recombinant full length human His6-tagged RSK4 expressed in baculovirus infected sf21 cells using biotin labelled Ahx-KKLNRTLSFAEPG pep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 17A(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50520168(CHEMBL4549459 | US10894784, Example 16.01.02)
Affinity DataKd:  9nMAssay Description:Inhibition of wild-type human partial length DRAK1 (R32 to E363 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50520168(CHEMBL4549459 | US10894784, Example 16.01.02)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of IKKepsilon/TBK1 in human MDB-MB-231 cells transduced with lentiviral vector expressing human IRF3 assessed as decrease in poly(I:C)-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50520168(CHEMBL4549459 | US10894784, Example 16.01.02)
Affinity DataIC50:  109nMAssay Description:Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50520168(CHEMBL4549459 | US10894784, Example 16.01.02)
Affinity DataIC50:  168nMAssay Description:Inhibition of recombinant full length human C-terminal GST-tagged IKKepsilon expressed in baculovirus expression system using biotin-labelled Ahx-GDE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50520168(CHEMBL4549459 | US10894784, Example 16.01.02)
Affinity DataIC50:  455nMAssay Description:Inhibition of recombinant full length human His-tagged CDK9/CyclinT1 expressed in baculovirus expression system using biotin-labelled Ttds-YISPLKSPYK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50520168(CHEMBL4549459 | US10894784, Example 16.01.02)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed in sf21 cells using biotin labelled Ahx-GGEEEEYFELVKKKK pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50520168(CHEMBL4549459 | US10894784, Example 16.01.02)
Affinity DataIC50:  2.27E+3nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed