BDBM50526737 CHEMBL4528500::US10807974, Example 82::US10995088, Example 82::US11608330, Example 82
SMILES Cc1ccc(cc1)-c1cc(ccc1S(C)(=O)=O)S(=O)(=O)c1ccc(CN)s1
InChI Key InChIKey=XXZVBBLROONNEG-UHFFFAOYSA-N
Data 21 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 50526737
Affinity DataIC50: 686nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
TargetProtein-lysine 6-oxidase(Mus musculus)
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: <180nMAssay Description:To produce MDCK cysts, cells were cultured on Matrigel (Corning) with 2% Matrigel supplemented in DMEM with 10% FBS. Cysts were allowed to form for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 min at room temp on a plate shaker.More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: 3.10E+4nMAssay Description:MAO-Glo Assay Kit: Promega, Cat No. V1402, MAO-A Enzyme: Promega, Cat No. V1452.More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: >1.00E+5nMAssay Description:MAO-Glo Assay Kit: Promega, Cat No. V1402, MAO-B Enzyme: Sigma, Cat No. M7441.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: >1.00E+5nMAssay Description:Promega ROS-Glo H2O2 Assay Kit, 50 ml. Cat No. G8821.More data for this Ligand-Target Pair
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: 770nMAssay Description:The following reagents were prepared:Reagents500 mM CHES, pH 9 (with NaOH), filtered (MW=207.29)20.7 g in 200 ml in dH2O10% Pluronic F-127 (store at ...More data for this Ligand-Target Pair
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: <180nMAssay Description:Cell Culture and TransfectionAll cell lines used in this study was purchased from American Type Culture Collection (ATCC). Mycoplasma contamination w...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:The following reagents were prepared:Reagents500 mM CHES, pH 9 (with NaOH), filtered (MW=207.29)20.7 g in 200 ml in dH2O10% Pluronic F-127 (store at ...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:10. Incubate for 1 hr at room temp on a plate shaker, protected from light.More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: 3.10E+4nMAssay Description:The following reagents were prepared:ReagentsMAO-Glo Assay Kit: Promega, Cat No. V1402MAO-A Enzyme: Promega, Cat No. V1452Clorgyline: Sigma, Cat No. ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: >1.00E+5nMAssay Description:The following reagents were prepared:ReagentsMAO-Glo Assay Kit: Promega, Cat No. V1402MAO-B Enzyme: Sigma, Cat No. M7441Deprenyl: Sigma, Cat No. M003...More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: >1.00E+5nMAssay Description:ReagentsPromega ROS-Glo H2O2 Assay Kit, 50 ml. Cat No. G8821Inhibitors (Test Compounds):10 mM stock diluted to 10, 3, 1, 0.3, 0.1, 0.03, 0.01, 0.003,...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Sus scrofa)
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: 770nMAssay Description:LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:MAO-Glo Assay Kit: Promega, Cat No. V1402MAO-A Enzyme: Promega, Cat No. V1452Clorgyline: Sigma, Cat No. M3778 (50 mg)Assay Plates:96 well white polys...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: 3.10E+4nMAssay Description:MAO-B Enzyme: Sigma, Cat No. M7441Deprenyl: Sigma, Cat No. M003Assay Plates: 96 well white polystyrene, flat bottom plates, no lid: Fisher, Cat No. D...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: >1.00E+5nMAssay Description:Promega ROS-Glo H2O2 Assay Kit, 50 ml. Cat No. G8821Inhibitors (Test compounds):10 mM stock diluted to 10, 3, 1, 0.3, 0.1, 0.03, 0.01, 0.003, 0.001, ...More data for this Ligand-Target Pair
TargetProtein-lysine 6-oxidase(Sus scrofa)
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
The Institute Of Cancer Research: Royal Cancer Hospital
US Patent
Affinity DataIC50: 770nMAssay Description:LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.More data for this Ligand-Target Pair