BDBM50527054 CHEMBL4453777

SMILES [H][C@]12CN(CCN1c1c(NC2=O)cnc2cc(c(Cl)cc12)-c1c(O)cccc1F)C(=O)C=C

InChI Key InChIKey=SBFNBXJLJDIRLI-GOSISDBHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50527054   

TargetGTPase KRas(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50527054(CHEMBL4453777)
Affinity DataIC50:  73nMAssay Description:Inhibition of KRAS G12C mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50527054(CHEMBL4453777)
Affinity DataIC50:  73nMAssay Description:Inhibition of GDP bound biotinylated human C-terminal Avi/His6-tagged KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed