BDBM50529395 CHEMBL4529672::US11731973, Example 21

SMILES CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)nc(N)nc12

InChI Key InChIKey=HGZOUPKZPOAOOQ-UHFFFAOYSA-N

Data  3 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50529395   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataKi:  3.80nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataKi:  150nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataIC50:  11nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataIC50:  4nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed